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anti aging face wrinkle HYALURONIC INTENSE SERUM Vitamin C Ester DMAE ALA skin    US $17.50

SKINFOOD] FRESH APPLE Sparkling Pore Serum SKIN FOOD Shipping In Stock    US $19.69

SKIN Organics By Ann Webb Serum Super Berry 1 Fluid Ounce sealed fresh    US $11.99

enspri Sheer Ceramide moisture locking protective serum 1 fl ozskin care New    US $34.50

SKIN SO SOFT Mineral Gems Shimmering Crystal Moisture Serum    US $2.99

Bath body works Pure SImplicity LICORICE anti aging skin brightening x2 serum    US $77.00

B5 Serum By Dermaquest Skin Therapy    US $62.00

Make Up Store SKIN SERUM Skincare System 1 oz    US $9.99

Clarins Hydraquench Intensive Serum Bi Phase Dehydrated Skin 15ml    US $20.15

PAULAS CHOICE Skin Recovery Super Antioxidant Concentrate Serum Eye 1 oz Tube    US $17.95

Serious Skin Care InstaGleam Facial Serum Moisturizer    US $6.99

SKIN FOOD Tomato Serum Whitening Skin Care 35ml    US $17.88

SKIN79] Total Power Serum 50ml    US $18.84

SERIOUS SKIN CARE SERAMINS SERUM DUO    US $12.99

SKIN FOOD] SKINFOOD Fresh Juice E Serum 50ml    US $15.85

Clarins Hydra Quench Intensive Serum Bi Phase dehydrated skin 3ml    US $1.56

Origins Brighter by Nature Skin Tone Correcting Serum 5 ml 17 oz    US $7.95

Serious Skin Care C Serum C Ester Skin Conditioner x 2    US $17.77

Seacret Dead Sea Concentrated Face Facial Skin Serum    US $24.95

Elizabeth Arden GOOD MORNING SKIN SERUM 05 oz    US $23.70

SKIN79] PORE LAB Pore Tightening Serum Pore Control    US $18.76

LOreal Skin Genesis serum concentrate    US $9.99

Phytomer Accept Oligoforce Soothing Serum 15ml05oz Sensitive Skin Fresh New    US $30.25

Dermalogica Skin Hydrating Booster Serum 8 Samples FRESH SAME DAY SHIPPING    US $6.99

SKIN FOOD] SKINFOOD Black Raspberry nutrient Serum    US $17.56

Seacret Dead Sea Concentrated Face Facial Skin Serum    US $23.95

ROC MULTI CORREXION Skin Renewing Serum 10 oz NEW BOX    US $17.09

skinfood Tomato Whitening Serum35ml Whitening Skin Care    US $13.00

SKIN FOOD] SKINFOOD Black Raspberry Su water Serum    US $17.99

SKIN FOOD] SKINFOOD Gold Kiwi Serum 50ml    US $18.84

SERIOUS SKIN CARE A FORCE XR SERUM 1 OZ NEW PACKAGING    US $14.99

NIB Estee Lauder Idealist Pore Minimizing Skin Refinisher 100ml 34oz NEW SERUM    US $150.00

Skin Medica TNS Essential Serum 10oz New In Box    US $163.99

SKIN FOOD] SKINFOOD Fresh Juice C Serum 50ml    US $17.70

Serious Skin Care INSTaGLEAM ILLUMINATING FACIAL SERUM    US $9.99

Its Skin Prestige Serum Descargot 60ml Plus Serum Eye Descargot 15ml    US $39.99

NAPOLEON PERDIS AUTO PILOT NAPOLEON COMPLEX SKIN RENEWAL SERUM 135OZ    US $33.89

MISSHA] Near Skin Vio White Inner Repairing Serum    US $25.70

LOREAL Skin Genesis MULTI Layer DAILY Eye SERUM 05oz    US $9.95

SKIN79 Total Power Serum 50ml All in One Toner Lotion Essence PrimerGift    US $19.88

SUM37˚ Time Energy Skin Resetting Repairing Serum 10ml1mlx10bags on SALE    US $7.10

Garnier Skin Renewing Daily Regenerating Serum 17 oz    US $10.18

2 KERI RENEWAL SERUM FOR DRY SKIN    US $6.19

ORIGINS Brighter by Nature Skin Tone Correcting Serum 15ml Travel NEW    US $17.99

2 RoC Multi Correxion Skin Renewing Serum 1 fl oz each    US $31.99

Juvena Renewing Body Serum Skin Nova Technology Switzeraland NEW 34oz    US $60.00

innisfree The green tea seed serum 80ml skin essence    US $24.65

SUM37˚ Time Energy Skin Resetting Repairing Serum 60mlOriginal SizeNew    US $62.00

MISSHA] Near Skin Firming Intensive Lifting Serum    US $25.70

BELLY MOTHERHOOD BODY FIRMING SERUM DAILY SKIN SUPPORT SERUM 4 FL OZ OZ 240 mL    US $14.99

COSMEDICINE MEGADOSE SKIN FORTIFYING ANTIOXIDANT SERUM 1OZ    US $33.96

In Box CLINIQUE PORE REFINING SOLUTIONS CORRECTING SERUM 17 oz ALL SKIN TYPES    US $5.99

PCA Skin Hydrating Serum 1 oz    US $64.00

Biore Skin Boosting Night Serum 14oz NEW    US $7.99

ONmacabim Neutrazen Nano Technology Serum Gel CPR For Couperose Skin    US $79.00

SKIN FOOD] SKINFOOD Egg White Serum 20ml X 2pcs Fast Shipping In Stock    US $11.99

S0203 Fresh Skin Oxygen Defensive Rescue Serum 30ml NEW    US $29.99

Keri Renewal Serum for Dry Skin Triple Action Formula    US $7.99

NEW 2 x ANTI AGEING FACE SERUM CREAM WRINKLE DARK SKIN 15ml NIB    US $20.53

Molton Brown Natural Skin Radiance Moonflower 01 Molton Brown brightening Serum    US $15.79

Biore Restore Skin Boosting Night Serum Oil Free DAILY RECHARGING 14 oz    US $9.99

MAKE UP STORE SKINCARE SYSTEM SKIN SERUM 1 OZ NEW UNBOXED    US $19.51

Origins Brighter By Nature Skin tone correcting serum 5 oz 15ml tube    US $17.99

Elizabeth Arden Good Morning Skin Serum 05oz 15ml New In Box    US $19.99

Elizabeth Arden Overnight Success Skin Renewal Serum 1 FL OZ FREE US SHIPPING    US $29.99

Elizabeth Arden Overnight Success Skin Renewal Serum    US $29.99

Elizabeth Arden Good Morning Skin Serum 05 oz    US $28.99

Ahava Mineral Beauty Serum For All Skin Types    US $60.07

NEW LOREAL AGE PERFECT RE CUSHIONING SERUM MATURE SKIN    US $11.99

SERIOUS SKIN CARE SERAMINS SERUM    US $6.99

Q10 SKIN SOLUTION INSTANT RESULT LIFTING SERUM1OZ    US $24.61

PAYOT RESSOURCE MINERALE PURIFYING SERUM 16OZCOMBINATION OILY SKIN    US $67.96

BIODYNAMIC SKIN SOLUTION FIRMING ULTRA HYDRATE SERUM    US $38.21

Serious Skincare C Serum Vitamin C Ester Skin Conditioner    US $12.95

Matis Intensive Purifying Serum Combination Oily Skin 30ml BULK SALE X 3 RRP$267    US $87.79

Stem Cell-Based Topical Serums for Renewal of Aging Skin

INTRODUCTION

Proper lifestyle, nutrition, exercise, and supplementation are crtitical for anti-aging in general, and specifically for anti-aging of the skin. Supplementation for healthy skin should include ingestion of micronutrients and omega-3 fatty acids for example, but should also include the topical application of nutrients that are both 1) needed by aging skin, and 2) absorbed by and available to the layers of the skin.

Evidence of aging skin appears in the facial and periorbital area and includes wrinkles, discoloration, eyelid bags, circles around the eye, and a sagging look. In the periorbital area, cheek descent and hollow tear trough, prolapse of orbital fat, skin laxity and sun damage, and eyelid fluid are the primary causes for the formation of lower eyelid bags.1Tear trough depression is characterized by loss of subcutaneous fat with thinning of the skin over the orbital rim ligaments combined with cheek descent. Orbital fat prolapse is recognized by the characteristic shape of the orbital fat compartments. Additionally, loss of skin elasticity is a critical feature of facial and eyelid aging, leading to facial wrinkles including Crow's feet, color and texture changes, and festoon formation. Eyelid fluid accumulation occurs with systemic edema or local edema such as that caused by facial allergy. Dark circles under the eyelid are another cosmetic concern for many individuals, and are primarily caused by a combination of melanocytosis or post-inflammatory hyperpigmentation.2Thinning of infraorbital skin and excessive vascularity making the subcutaneous blood vessels more visible is believed to be the second common primary cause of dark circles.2 Previous studies indicate that topical application of growth factors is able to diminish the effects associated with aging skin (3). The present study investigated a novel skin serum derived from adult stem cells  that contained a proprietary mixture of human growth factors, antioxidants, and cytokines for facial skin rejuvenation, including periorbital rejuvenation. The mixture of factors is obtained through a proprietary biotechnology process using combinations of cultured adult stem cells. Facial skin, particularly eyelid skin is the thinnest in the body, of a fragile nature, and important to visual function making the area particularly difficult to treat.

MATERIALS AND METHODS

Subjects Males and females between 35 to 80 years of age of good general health not nursing or pregnant with demonstrable fine or deep wrinkles in the face, including around both eyes, at least barely visible dark areas, and at least slightly coarse and grainy lower eyelids. Subjects with any active or any history of skin disease affecting the face area or under the eyes were not included. In addition, subjects were asked to stop their current regime of using any products that may enhance skin condition and aid in reduction of wrinkles. Make-up and sunscreens were permitted. Subjects, who have undergone cosmetic surgery affecting facial skin within 6 months, were also excluded from the study.

Treatment regimen

BRS Vital Serum was applied in mornings and evenings to the facial skin, including the peri-orbital skin area over a period of six weeks (42 days). Subjects were asked to document each application of BRS Vital Serum.

Evaluation at baseline and after 6 weeks

Subjects were evaluated by:

1- Clinical assessment:

• Clinical photography under standardized conditions.
• Where available, the VISIA-CR imaging system (Canfield Scientific, Inc., Fairfield, NJ) was used
• Clinical assessment of skin quality, including the peri-orbital skin using 1- to 10-point visual scoring system given in Table 1

2- Self-assessment:

• Quality of facial skin, including the peri-orbital skin by subject using questionnaire given

RESULTS

Of the 40 subjects enrolled, 40 subjects averaged 54 years of age (between 35 to 80 years) completed the study. Results were tabulated using scores generated by the clinical evaluationsand subject questionnaire. All results showed a statistical significant of p= 0.05. All subjects (100%) reported to have tolerated the skin serum well, and 100% of subjects liked the way the skin serum felt, while 100% would continue its regular use after the six weeks study period. Improvement is shown as difference between the averaged score before (baseline) and the averaged score after treatment expressed in percentages of the averaged baseline score and includes all 40 subjects completing the study.

In conjunction with this study, we performed a comparison study, comparing BRS Vital Serum to other products of similar properties or claim similar properties. This study served two purposes; 1) to show how effective BRS Vital Serum compared to other products in the market, and 2) be used as a negative control for the study in addition to using a placebo. Measuring 8 factors, including 1. wrinkle dimension, 2. Texture, 3. pore size, 4. sagging, 5. puffiness, 6. dark spots, 7. UV spots, and 8. staining, BRS Vital Serum showed a 31% better score than several other state-of-the-art products on the market.

CONCLUSIONS

The present study demonstrated that a skin serum (BRS Vital Serum) containing a proprietary mixture of human stem cell derived growth factors and cytokines combined with antioxidant factors is safe and efficacious for facial skin rejuvenation in cases of mild to moderate skin aging. The serum's efficacy, excellent tolerability, including the delicate periorbital skin area, and ease of use and pleasant sensory properties of the product explain why 100% would continue regular use of Vital Serum.

REFERENCES

[1] Goldberg R.A. et al., Plast Reconstr Surg 2005; 115: 1395-1402.

[2] Epstein J.S., Arch Facial Plast Surg 1999; 1: 303-307.

[3] Maguire, G. 2007: BioRegenerative Sciences, Inc. White Paper

[4]Gold M.H., Goldman M.P. and Biron J., J Drugs Dermatol 2007, 6:1018.

[5] Manaloto R.M.P. and Alster T.S., Dermatol Surg 1999; 25: 1-9.

About the Author

Dr. Maguire is CEO and Co-Founder of BioRegenerative Sciences, Inc.,of San Diego, California, USA. Maguire is a NIH-supported research scientists, professors at medical school, with numerous peer-reviewed publications. Maguire was awarded the NIH's prestigious Fogarty Fellowship for his work in studying the nervous system. Dr. Maguire has been working on stem cells dating back to 1997. Email gmaguire@bioregenerativesciences.com

Dr. Maguire's Blog: http://healthstemcellstechnology.blogspot.com/